ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting.

@article{Zhang1999ARF6IR,
  title={ARF6 is required for growth factor- and rac-mediated membrane ruffling in macrophages at a stage distal to rac membrane targeting.},
  author={Q K Zhang and Jero Calafat and Hans W R M Janssen and Steven M Greenberg},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 12},
  pages={8158-68}
}
Activation of Rac1, a member of the Rho family of GTPases, is associated with multiple cellular responses, including membrane ruffling and focal complex formation. The mechanisms by which Rac1 is coupled to these functional responses are not well understood. It was recently shown that ARF6, a GTPase implicated in cytoskeletal alterations and a membrane… CONTINUE READING