ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.

@article{Kondo2012ARF1AA,
  title={ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.},
  author={Yumika Kondo and Ayako Hanai and Waka Nakai and Yohei Katoh and Kazuhisa Nakayama and Hye-Won Shin},
  journal={Cell structure and function},
  year={2012},
  volume={37 2},
  pages={141-54}
}
Small GTPases ARF1 and ARF3 localize mainly to the Golgi apparatus, where they trigger formation of coated carrier vesicles. We previously showed that BIG2, a guanine nucleotide exchange factor specific for ARF1 and ARF3, localizes not only to the trans-Golgi network (TGN) but also to recycling endosomes, where it is involved in regulating the integrity of recycling endosomes. However, it is not yet clear whether ARF1 and ARF3 act downstream of BIG2 to ensure endosome integrity. In this study… CONTINUE READING