ARF triggers cell G1 arrest by a P53 independent ERK pathway

Abstract

In this study, in order to investigate the p53-independent function of p14ARF, we established p14ARF-inducible clones in the p53-deficient HCT cell line using the doxycycline-inducible expression system. A strong cell growth inhibition and G1/S arrest were observed after doxycycline induction in p53-/-HCT cells, and the cells also exhibited an obvious… (More)
DOI: 10.1007/s11010-011-0912-4

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@article{Du2011ARFTC, title={ARF triggers cell G1 arrest by a P53 independent ERK pathway}, author={Hansong Du and Weiqi Yao and Min Fang and Dongcheng Wu}, journal={Molecular and Cellular Biochemistry}, year={2011}, volume={357}, pages={415-422} }