ARF proteins mediate insulin-dependent activation of phospholipase D

@article{Shome1997ARFPM,
  title={ARF proteins mediate insulin-dependent activation of phospholipase D},
  author={Kuntala Shome and Chandrasekaran Vasudevan and Guillermo Romero},
  journal={Current Biology},
  year={1997},
  volume={7},
  pages={387-396}
}
BACKGROUND ADP-ribosylation factors (ARFs) have been shown to activate phospholipase D (PLD), an enzyme modulated by extracellular signals, including several growth factors and, in particular, insulin. We have tested the hypothesis that ARF proteins are involved specifically in insulin-induced activation of PLD. RESULTS We found that in membranes obtained from HIRcB cells, a cell line derived from Rat-1 fibroblasts that overexpresses normal human insulin receptors, binding of the GTP analogue… CONTINUE READING

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Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor.

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