ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex

  title={ARF mediates recruitment of PtdIns-4-OH kinase-β and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex},
  author={Anna Godi and Paolo Pertile and Rachel Meyers and Pierfrancesco Marra and Giuseppe Di Tullio and Cristiano Iurisci and Alberto Luini and Daniela Corda and Maria Antonietta De Matteis},
  journal={Nature Cell Biology},
The small GTPase ADP-ribosylation factor (ARF) regulates the structure and function of the Golgi complex through mechanisms that are understood only in part, and which include an ability to control the assembly of coat complexes and phospholipase D (PLD). Here we describe a new property of ARF, the ability to recruit phosphatidylinositol-4-OH kinase-β and a still unidentified phosphatidylinositol-4-phosphate-5-OH kinase to the Golgi complex, resulting in a potent stimulation of synthesis of… CONTINUE READING
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