ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.

  title={ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence.},
  author={Linan Ha and Takeshi Ichikawa and Miriam Anver and Ross A Dickins and S. Lowe and Norman E Sharpless and Paul J. A. Krimpenfort and Ronald A. Depinho and Dorothy C Bennett and Elena V Sviderskaya and Glenn Merlino},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={104 26},
Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we show that genetic deficiency in Arf but not p53 facilitates rapid development of melanoma in a genetically engineered mouse model. This difference is accounted for, at least in part… CONTINUE READING

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