ARF family G proteins and their regulators: roles in membrane transport, development and disease

@article{Donaldson2011ARFFG,
  title={ARF family G proteins and their regulators: roles in membrane transport, development and disease},
  author={Julie G Donaldson and Catherine L Jackson},
  journal={Nature Reviews Molecular Cell Biology},
  year={2011},
  volume={12},
  pages={362-375}
}
Members of the ADP-ribosylation factor (ARF) family of guanine-nucleotide-binding (G) proteins, including the ARF-like (ARL) proteins and SAR1, regulate membrane traffic and organelle structure by recruiting cargo-sorting coat proteins, modulating membrane lipid composition, and interacting with regulators of other G proteins. New roles of ARF and ARL proteins are emerging, including novel functions at the Golgi complex and in cilia formation. Their function is under tight spatial control… CONTINUE READING
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