ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor

  title={ARF-BP1/Mule Is a Critical Mediator of the ARF Tumor Suppressor},
  author={Delin Chen and Ning Kon and Muyang Li and Wenzhu Zhang and Jun Qin and Wei Gu},
Although the importance of the ARF tumor suppressor in p53 regulation is well established, numerous studies indicate that ARF also suppresses cell growth in a p53/Mdm2-independent manner. To understand the mechanism of ARF-mediated tumor suppression, we identified a ubiquitin ligase, ARF-BP1, as a key factor associated with ARF in vivo. ARF-BP1 harbors a signature HECT motif, and its ubiquitin ligase activity is inhibited by ARF. Notably, inactivation of ARF-BP1, but not Mdm2, suppresses the… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 85 references

p 14 ARF nduces G 2 cell cycle arrest in p 53and p 21deficient cells by ownregulating p 34 cdc 2 kinase activity

G. ormand, P. G. Hemmati, +6 authors P. T. Daniel
J . Biol . Chem . • 2005

A dynamic role of tHAUSP in the p 53Mdm 2 pathway

M. S TLi, C. L. Brooks, N. Kon, W. Gu
Mol . Cell • 2004

Rp 19 ( Arf ) suppresses growth , progression , and metastasis of Hrasdriven carcinomas through p 53dependent and independent pathP ways

K. S. PKelly-Spratt, K. E. Gurley, Y. Yasui, C. J. Kemp
PLoS Biol . • 2004

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