ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins

@article{Bakheet2001AREDHA,
  title={ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins},
  author={Tala Bakheet and Mathias Frevel and Bryan R. G. Williams and William Greer and Khalid S. A. Khabar},
  journal={Nucleic acids research},
  year={2001},
  volume={29 1},
  pages={246-54}
}
The adenylate uridylate-rich elements (AREs) mediate the rapid turnover of mRNAs encoding proteins that regulate cellular growth and body response to exogenous agents such as microbes, inflammatory and environmental stimuli. However, the full repertoire of ARE-containing mRNAs is unknown. Here, we explore the distribution of AREs in human mRNA sequences. Computational derivation of a 13-bp ARE pattern was performed using multiple expectation maximization for motif elicitations (MEME) and… CONTINUE READING
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