ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome.

@article{Durante2002ARDSNetLT,
  title={ARDSNet lower tidal volume ventilatory strategy may generate intrinsic positive end-expiratory pressure in patients with acute respiratory distress syndrome.},
  author={Gabriella de Durante and Monica del Turco and Laura Rustichini and Patrizia Cosimini and Francesco Giunta and Leonard D. Hudson and Arthur S Slutsky and V. Marco Ranieri},
  journal={American journal of respiratory and critical care medicine},
  year={2002},
  volume={165 9},
  pages={1271-4}
}
The ARDSNet trial revealed that the use of a smaller tidal volume (VT) reduced mortality by 22%. However, three earlier studies that lowered VT did not find a decrease in mortality. We tested the hypothesis that the increased respiratory rate used in the ARDSNet lower VT strategy might have led to intrinsic positive end-expiratory pressure (PEEP(i)), raising total PEEP (PEEP(total)). Ten patients with acute respiratory distress syndrome (ARDS) were ventilated using the ARDSNet lower VT protocol… CONTINUE READING