ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context

@article{Margolin2006ARACNEAA,
  title={ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context},
  author={Adam A. Margolin and Ilya Nemenman and Katia Basso and Chris Wiggins and Gustavo Stolovitzky and Riccardo Dalla Favera and Andrea Califano},
  journal={BMC Bioinformatics},
  year={2006},
  volume={7},
  pages={S7 - S7}
}
Elucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genome-wide "reverse engineering" of such networks have been successful only for lower eukaryotes with simple genomes. Here we present ARACNE, a novel algorithm, using microarray expression profiles, specifically designed to scale up to the complexity of regulatory networks in mammalian cells, yet general enough to address a wider… CONTINUE READING
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