ARACHNE: a whole-genome shotgun assembler.

@article{Batzoglou2002ARACHNEAW,
  title={ARACHNE: a whole-genome shotgun assembler.},
  author={Serafim Batzoglou and David B. Jaffe and Ken Stanley and Jonathan L. Butler and Sante Gnerre and Evan Mauceli and Bonnie Berger and Jill P. Mesirov and Eric S. Lander},
  journal={Genome research},
  year={2002},
  volume={12 1},
  pages={177-89}
}
We describe a new computer system, called ARACHNE, for assembling genome sequence using paired-end whole-genome shotgun reads. ARACHNE has several key features, including an efficient and sensitive procedure for finding read overlaps, a procedure for scoring overlaps that achieves high accuracy by correcting errors before assembly, read merger based on forward-reverse links, and detection of repeat contigs by forward-reverse link inconsistency. To test ARACHNE, we created simulated reads… CONTINUE READING
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Toward Simplifying and Accurately Formulating Fragment Assembly

Journal of Computational Biology • 1995
View 5 Excerpts
Highly Influenced

CAP3: A DNA sequence assembly program.

Genome research • 1999
View 5 Excerpts
Highly Influenced

PHRAP documentation

P. Green
http://www.phrap.org. • 1994
View 5 Excerpts
Highly Influenced

Analysis of the genome sequence of the flowering plant Arabidopsis thaliana

Arabidopsis Genome Initiative.
Nature 408: 796–815. • 2000

Computational genomics: Mapping, comparison, and annotation of genomes.

S. Batzoglou
Ph.D. dissertion, Massachusetts Institute of Technology, • 2000

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