ARACHNE: a whole-genome shotgun assembler.

  title={ARACHNE: a whole-genome shotgun assembler.},
  author={Serafim Batzoglou and David B. Jaffe and Ken Stanley and Jonathan L. Butler and Sante Gnerre and Evan Mauceli and Bonnie Berger and Jill P. Mesirov and Eric S. Lander},
  journal={Genome research},
  volume={12 1},
We describe a new computer system, called ARACHNE, for assembling genome sequence using paired-end whole-genome shotgun reads. ARACHNE has several key features, including an efficient and sensitive procedure for finding read overlaps, a procedure for scoring overlaps that achieves high accuracy by correcting errors before assembly, read merger based on forward-reverse links, and detection of repeat contigs by forward-reverse link inconsistency. To test ARACHNE, we created simulated reads… CONTINUE READING
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