AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression

@inproceedings{Li2012ARID,
  title={AR intragenic deletions linked to androgen receptor splice variant expression and activity in models of prostate cancer progression},
  author={Yingming Li and Tae Hyun Hwang and Leann Oseth and Adam Hauge and Robert L. Vessella and Stephen C. Schmechel and Betsy Hirsch and Kenneth Beckman and Kevin A. T. Silverstein and Scott M Dehm},
  booktitle={Oncogene},
  year={2012}
}
Reactivation of the androgen receptor (AR) during androgen depletion therapy (ADT) underlies castration-resistant prostate cancer (CRPCa). Alternative splicing of the AR gene and synthesis of constitutively active COOH-terminally truncated AR variants lacking the AR ligand-binding domain has emerged as an important mechanism of ADT resistance in CRPCa. In a previous study, we demonstrated that altered AR splicing in CRPCa 22Rv1 cells was linked to a 35-kb intragenic tandem duplication of AR… CONTINUE READING