AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.

@article{Bertolotti2016AQP8TN,
  title={AQP8 transports NOX2-generated H2O2 across the plasma membrane to promote signaling in B cells.},
  author={Milena Bertolotti and Giada Farinelli and Mauro Galli and Alessandro Aiuti and Roberto Sitia},
  journal={Journal of leukocyte biology},
  year={2016},
  volume={100 5},
  pages={
          1071-1079
        }
}
H2O2 acts as a second messenger in key signaling circuits, transiently modulating tyrosine phosphatases and kinases. We investigated its origin, membrane transport, and functional role during B cell activation and differentiation. Our data identified NADPH-oxidase 2 as the main source of H2O2 and aquaporin 8 as a transport facilitator across the plasma membrane. On aquaporin 8 silencing, inducible B lymphoma cells responded poorly to TLR and BCR stimulation. Their differentiation was severely… CONTINUE READING
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