APRIL modulates B and T cell immunity.

  title={APRIL modulates B and T cell immunity.},
  author={Jens V. Stein and Marta L{\'o}pez-Fraga and Fernando A Elustondo and Carla Eponina Carvalho-Pinto and Dolores Rodr{\'i}guez and Ruth G{\'o}mez-Caro and Joan H. de Jong and Carlos Mart{\'i}nez-A and Jan Paul Medema and Michael Hahne},
  journal={The Journal of clinical investigation},
  volume={109 12},
The TNF-like ligands APRIL and BLyS are close relatives and share the capacity to bind the receptors TACI and BCMA. BLyS has been shown to play an important role in B cell homeostasis and autoimmunity, but the biological role of APRIL remains less well defined. Analysis of T cells revealed an activation-dependent increase in APRIL mRNA expression. We therefore generated mice expressing APRIL as a transgene in T cells. These mice appeared normal and showed no signs of B cell hyperplasia… CONTINUE READING