APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.

@article{Tai2016APRILAB,
  title={APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment.},
  author={Yu-Tzu Tai and C Acharya and Gang An and Michele Moschetta and Mike Y. Zhong and Xiaoyan Feng and Michele Cea and Antonia Cagnetta and Kenneth Wen and Hans van Eenennaam and Andrea van Elsas and Lugui Qiu and Paul G Richardson and Nikhil C. Munshi and Kenneth C. Anderson},
  journal={Blood},
  year={2016},
  volume={127 25},
  pages={3225-36}
}
Here we show that overexpression or activation of B-cell maturation antigen (BCMA) by its ligand, a proliferation-inducing ligand (APRIL), promotes human multiple myeloma (MM) progression in vivo. BCMA downregulation strongly decreases viability and MM colony formation; conversely, BCMA overexpression augments MM cell growth and survival via induction of protein kinase B (AKT), MAPK, and nuclear factor (NF)-κB signaling cascades. Importantly, BCMA promotes in vivo growth of xenografted MM cells… CONTINUE READING
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Classical and/or alternative NF-kappaB pathway activation in BLOOD, 23 JUNE 2016 x VOLUME 127, NUMBER 25 APRIL/BCMA PATHWAY IN MM PATHOPHYSIOLOGY

YN Demchenko, OK Glebov, +3 authors WM. Kuehl
For personal use only. on September • 2016

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