APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons.

@article{Kloskowska2008APPsweMI,
  title={APPswe mutation increases the frequency of spontaneous Ca2+-oscillations in rat hippocampal neurons.},
  author={Ewa Kloskowska and Katarzyna Malkiewicz and Bengt Winblad and Eir{\'i}kur Benedikz and Joseph D. Bruton},
  journal={Neuroscience letters},
  year={2008},
  volume={436 2},
  pages={250-4}
}
Altered calcium homeostasis is implicated in the pathogenesis of Alzheimer's disease (AD). Much effort has been put into understanding the association between protein mutations causative of this devastating neurodegenerative disease and perturbed calcium signaling. Whereas the presenilin mutations have received most attention in the context of neuronal… CONTINUE READING