APPLied mechanics: uncovering how adiponectin modulates insulin action.

@article{Hosch2006APPLiedMU,
  title={APPLied mechanics: uncovering how adiponectin modulates insulin action.},
  author={Sarah E Hosch and Jerrold M. Olefsky and Jane Kim},
  journal={Cell metabolism},
  year={2006},
  volume={4 1},
  pages={5-6}
}
Adiponectin, an adipocyte secretory hormone, has been causally linked to insulin resistance in the metabolic syndrome and diabetes. A recent paper (Mao et al., 2006) shows that the APPL1 adaptor protein binds to the intracellular domain of adiponectin receptors and mediates some of adiponectin's actions, identifying a novel mechanism linking adiponectin to insulin sensitization. 
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