APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.

Abstract

The amyloid (Abeta) peptides generated in Hsiao's APP Tg2576 transgenic (Tg) mice are physically and chemically distinct from those characteristic of Alzheimer's disease (AD). Transgenic mouse Abeta peptides were purified using sequential size-exclusion and reverse-phase chromatographic systems and subjected to amino acid sequencing and mass spectrometry… (More)

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@article{Kalback2002APPTM, title={APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.}, author={Walter M. Kalback and Michael D. Watson and Tyler A. Kokjohn and Yu-Min Kuo and Nicole H. Weiss and Dean C Luehrs and John Lopez and Daniel C. Brune and Sangram S. Sisodia and Matthias Staufenbiel and Mark R. Emmerling and Alex E. Roher}, journal={Biochemistry}, year={2002}, volume={41 3}, pages={922-8} }