APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.

@article{Jankowsky2004APPPA,
  title={APP processing and amyloid deposition in mice haplo-insufficient for presenilin 1.},
  author={Joanna L. Jankowsky and Hilda H. Slunt and V. Gonzales and Nancy A. Jenkins and Neal G. Copeland and David R Borchelt},
  journal={Neurobiology of aging},
  year={2004},
  volume={25 7},
  pages={885-92}
}
More than 70 different mutations in presenilin 1 (PS1) have been associated with inherited early onset Alzheimer's disease (AD). How all these different mutations cause disease has not been clearly delineated. Our laboratory has previously shown that co-expression of mutant PS1 in mice transgenic for amyloid precursor protein (APPswe) dramatically accelerates the rate of amyloid deposition in the brain. In our original animals mutant PS1 was substantially over-expressed, and the stabilized pool… CONTINUE READING
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