APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

  title={APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.},
  author={Robert Tamayev and Shuji Matsuda and Luca Giliberto and Ottavio Arancio and Luciano D'Adamio},
  journal={The EMBO journal},
  volume={30 12},
An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia (FDD). Analysis of FDD(KI) mice, a mouse model of FDD genetically congruous to the human disease since they carry one mutant and one wild-type Bri2/Itm2b allele, has shown that the Danish mutation causes loss of Bri2 protein, synaptic plasticity and memory impairments. BRI2 is a physiological interactor of Aβ-precursor protein (APP), a gene associated with Alzheimer disease, which inhibits processing of APP… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 25 extracted citations

Lessons from a Rare Familial Dementia: Amyloid and Beyond

Journal of Parkinson's disease and Alzheimer's disease • 2015
View 18 Excerpts
Highly Influenced

APP Receptor? To Be or Not To Be.

Trends in pharmacological sciences • 2016
View 7 Excerpts
Highly Influenced

BRI2 as an anti-Alzheimer gene

Medical Molecular Morphology • 2018

Can agrin CSF concentration be used as an early biomarker for Alzheimer ’ s disease ?

Marta Del Campo Leah Zuroff Connie R. Jimenez Carsten Ko Teunissen
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 45 references

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2010
View 1 Excerpt

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

Proceedings of the National Academy of Sciences of the United States of America • 2009

An NSAIDlike compound , FT9 , preferentially inhibits gammasecretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursorlike protein 1

C SalaFrigerio, TL Kukar, +3 authors DM Walsh
Biochemistry • 2009

Similar Papers

Loading similar papers…