APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.

@article{Tamayev2011APPHA,
  title={APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant.},
  author={Robert Tamayev and Shuji Matsuda and Luca Giliberto and Ottavio Arancio and Luciano D'Adamio},
  journal={The EMBO journal},
  year={2011},
  volume={30 12},
  pages={2501-9}
}
An autosomal dominant mutation in the BRI2/ITM2B gene causes familial Danish dementia (FDD). Analysis of FDD(KI) mice, a mouse model of FDD genetically congruous to the human disease since they carry one mutant and one wild-type Bri2/Itm2b allele, has shown that the Danish mutation causes loss of Bri2 protein, synaptic plasticity and memory impairments. BRI2 is a physiological interactor of Aβ-precursor protein (APP), a gene associated with Alzheimer disease, which inhibits processing of APP… CONTINUE READING

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