APP Processing and the APP-KPI Domain Involvement in the Amyloid Cascade

@article{MenndezGonzlez2005APPPA,
  title={APP Processing and the APP-KPI Domain Involvement in the Amyloid Cascade},
  author={Manuel Men{\'e}ndez-Gonz{\'a}lez and Pablo P{\'e}rez-Pi{\~n}era and Marta Mart{\'i}nez-Rivera and Mar{\'i}a Teresa Calatayud and B Bl{\'a}zquez Menes},
  journal={Neurodegenerative Diseases},
  year={2005},
  volume={2},
  pages={277 - 283}
}
Alternative APP mRNA splicing can generate isoforms of APP containing a Kunitz protease inhibitor (KPI) domain. KPI is one of the main serine protease inhibitors. Protein and mRNA KPI(+)APP levels are elevated in Alzheimer’s disease (AD) brain and are associated with increased amyloid beta deposition. In the last years increasing evidence on multiple points in the amyloid cascade where KPI(+)APP is involved has been accumulated, admitting an outstanding position in the pathogenesis of AD to the… 

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