APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones

@inproceedings{Laek2017APPDA,
  title={APP Deletion Accounts for Age-Dependent Changes in the Bioenergetic Metabolism and in Hyperphosphorylated CaMKII at Stimulated Hippocampal Presynaptic Active Zones},
  author={Melanie La\ssek and Jens Weingarten and Martin Wegner and Moritz Neupaertl and Tabiwang N. Array and Eva Harde and Benedikt Beckert and Vahid Golghalyani and J{\"o}rg Ackermann and Ina Koch and Ulrike C M{\"u}ller and Michael Karas and Amparo Acker-Palmer and Walter Volknandt},
  booktitle={Front. Synaptic Neurosci.},
  year={2017}
}
Synaptic release sites are characterized by exocytosis-competent synaptic vesicles tightly anchored to the presynaptic active zone (PAZ) whose proteome orchestrates the fast signaling events involved in synaptic vesicle cycle and plasticity. Allocation of the amyloid precursor protein (APP) to the PAZ proteome implicated a functional impact of APP in neuronal communication. In this study, we combined state-of-the-art proteomics, electrophysiology and bioinformatics to address protein abundance… CONTINUE READING
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