APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.

@article{Sheline2010APOE4AD,
  title={APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.},
  author={Yvette I. Sheline and John C. Morris and Abraham Z. Snyder and Joseph L. Price and Zhizi Yan and Gina D'Angelo and Collin Y. Liu and Sachin Dixit and Tammie L. Benzinger and Anne M. Fagan and Alison M. Goate and Mark A. Mintun},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2010},
  volume={30 50},
  pages={17035-40}
}
Identifying high-risk populations is an important component of disease prevention strategies. One approach for identifying at-risk populations for Alzheimer's disease (AD) is examining neuroimaging parameters that differ between patients, including functional connections known to be disrupted within the default-mode network. We have previously shown these same disruptions in cognitively normal elderly who have amyloid-β (Aβ) plaques [detected using Pittsburgh Compound B (PIB) PET imaging… CONTINUE READING
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Alzheimer’s Disease Neuroimaging Initiative

  • DA Wolk, BC Dickerson
  • Proc Natl Acad Sci U S A
  • 2010

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