APOE-induced microglial activation: an in vitro assay to screen sera from Alzheimer's disease patients and novel therapeutic compounds.

@article{Lombardi1998APOEinducedMA,
  title={APOE-induced microglial activation: an in vitro assay to screen sera from Alzheimer's disease patients and novel therapeutic compounds.},
  author={Valter R. M. Lombardi and Miguel Latorre Garc{\'i}a and R Cacabelow},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1998},
  volume={20 5},
  pages={377-86}
}
Recent advances in molecular genetics have suggested that genetic predisposition can be considered one of the most important risk factors for Alzheimer's disease (AD) development. A significant increase in the number of amyloid plaques in AD patients with an apolipoprotein E4 (APOE) allele has been observed and the results of several genetic studies indicate that the etiology of this neurodegenerative disease is associated with the presence of the allele E4 of APOE gene. A potential source of… CONTINUE READING