APOE genotype and cognitive change in young, middle-aged, and older adults living in the community.

Abstract

We examined whether the apolipoprotein E (APOE) ε4 allele was associated with cognitive benefits in young adulthood and whether it reversed to confer cognitive deficits in later life ("antagonistic pleiotropy") in the absence of dementia-related neuropathology. We also tested whether the ε2 allele was associated with disadvantages in early adulthood but… (More)
DOI: 10.1093/gerona/glt103

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