APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.

@article{Lynch2003APOEGA,
  title={APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response.},
  author={John R. Lynch and Wen Lu Tang and Haichen Wang and Michael P Vitek and Ellen R. Bennett and Patrick M Sullivan and David Sjoquist Nick Warner and Daniel T Laskowitz},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 49},
  pages={48529-33}
}
Human apolipoprotein E is the major apolipoprotein expressed in the brain and exists as three isoforms, designated E2, E3, and E4. Although evidence suggests that apolipoprotein E plays an important role in modifying systemic and brain inflammatory responses, there is little data investigating apoE isoform-specific effects in vivo. In this study, we compared the inflammatory responses of targeted-replacement mice expressing the human APOE3 and APOE4 genes after intravenous administration of… CONTINUE READING

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