APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals.

@article{Dumanis2013APOEGA,
  title={APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals.},
  author={Sonya B Dumanis and Amanda M Dibattista and Matthew J Miessau and Charbel Moussa and George William Rebeck},
  journal={Journal of neurochemistry},
  year={2013},
  volume={124 1},
  pages={4-14}
}
Apolipoprotein E (APOE) genotype affects outcomes of Alzheimer's disease and other conditions of brain damage. Using APOE knock-in mice, we have previously shown that APOE-ε4 Targeted Replacement (TR) mice have fewer dendritic spines and reduced branching in cortical neurons. As dendritic spines are post-synaptic sites of excitatory neurotransmission, we used APOE TR mice to examine whether APOE genotype affected the various elements of the glutamate-glutamine cycle. We found that levels of… CONTINUE READING
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