APOE-epsilon4 predisposes to cognitive dysfunction following uncomplicated carotid endarterectomy.

@article{Heyer2005APOEepsilon4PT,
  title={APOE-epsilon4 predisposes to cognitive dysfunction following uncomplicated carotid endarterectomy.},
  author={Eric J. Heyer and Dyanne A. Wilson and Daniel H Sahlein and J D Mocco and Steven C. R. Williams and Robert Sciacca and Anita Rampersad and Ricardo J. Komotar and Joseph Zurica and Alan I Benvenisty and Donald O. Quest and George Todd and Robert A. Solomon and E Sander Connolly},
  journal={Neurology},
  year={2005},
  volume={65 11},
  pages={1759-63}
}
BACKGROUND Between 9% and 23% of patients undergoing otherwise uncomplicated carotid endarterectomy (CEA) develop subtle cognitive decline 1 month postoperatively. The APOE-epsilon4 allele has been associated with worse outcome following stroke. OBJECTIVE To investigate the ability of APOE-epsilon4 to predict post-CEA neurocognitive dysfunction. METHODS Seventy-five patients with CEA undergoing elective CEA were prospectively recruited in this nested cohort study and demographic variables… CONTINUE READING
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