APOE epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old.

@article{Juva2000APOEED,
  title={APOE epsilon4 does not predict mortality, cognitive decline, or dementia in the oldest old.},
  author={Kati Juva and Auli Verkkoniemi and Petteri Viramo and Tuomo M. Polvikoski and Katariina Kainulainen and Kimmo K. Kontula and Raimo O Sulkava},
  journal={Neurology},
  year={2000},
  volume={54 2},
  pages={412-5}
}
OBJECTIVE To examine the effect of the epsilon 4 allele on cognitive decline in the oldest old. METHODS We studied all 601 citizens of the city of Vantaa age 85 years and older in 1991. A total of 553 subjects (92%) took part in the study, which used the Mini-Mental State Examination (MMSE) and assessment of dementia according to the Diagnostic and Statistical Manual of Mental Disorders, third ed., revised (DSM-III-R) criteria. The survivors were re-examined 3 years later. APOE genotype was… CONTINUE READING