APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors.

@article{Spector2010APOEEA,
  title={APOE epsilon4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors.},
  author={Stephen A Spector and Kumud Singh and Saurabh Gupta and Lucette A Cystique and Hua Jin and Scott L Letendre and Rachel D. Schrier and Zunyou Wu and Kun Xue Hong and Xin Yu and Chuan Shi and Robert K. Heaton},
  journal={AIDS},
  year={2010},
  volume={24 10},
  pages={1471-9}
}
BACKGROUND Host genetic factors are important determinants for risk of HIV-1 infection and disease progression. This study examined associations of host genetic variants and neurocognitive impairment in Chinese individuals infected through contaminated blood products. METHODS Two hundred and one HIV-infected patients from Anhui, China, had neuropsychological tests at baseline and 12 months. DNA was genotyped for APOE epsilon2, epsilon3 and epsilon4 alleles; MBL2-A/O; CCR5-wt/Delta32; CCR5… CONTINUE READING