APOE-epsilon3 and APOE-219G haplotypes increase the risk for schizophrenia in sibling pairs.

@article{TovillaZrate2009APOEepsilon3AA,
  title={APOE-epsilon3 and APOE-219G haplotypes increase the risk for schizophrenia in sibling pairs.},
  author={Carlos Alfonso Tovilla-Z{\'a}rate and Beatriz Camarena Medell{\'i}n and Ana Fres{\'a}n and Rogelio Apiquian and Albana M Dassori and Medina Rolando and Michael Escamilla and Humberto Nicolini},
  journal={The Journal of neuropsychiatry and clinical neurosciences},
  year={2009},
  volume={21 4},
  pages={440-4}
}
To investigate the role of the apolipoprotein E (APOE) gene in schizophrenia, the authors analyzed 60 families with this mental disorder. An association in the presence of linkage test (APL) and haplotypes analysis were undertaken using the APL v1.1 software. A global allelic transmitted was significant for APOE-epsilon3 (chi(2)=6.24, p=0.01); this allele… CONTINUE READING