APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old.

@article{Berlau2009APOEEI,
  title={APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old.},
  author={Daniel J Berlau and Mar{\'i}a M. Corrada and Elizabeth Head and Claudia H. Kawas},
  journal={Neurology},
  year={2009},
  volume={72 9},
  pages={829-34}
}
BACKGROUND Many studies have examined the role of APOE genotype in the development of dementia, specifically Alzheimer disease (AD). The APOE epsilon4 allele (APOE4) is a risk factor for both clinical and neuropathologic AD whereas the APOE epsilon2 allele (APOE2) seems to be protective. This would predict, even with advanced age, that APOE2 carriers would… CONTINUE READING