APOE epsilon-4 allele and cytokine production in Alzheimer's disease.

  title={APOE epsilon-4 allele and cytokine production in Alzheimer's disease.},
  author={Paolo Olgiati and Antonis Politis and Petros N Malitas and D Albani and Sabrina Dusi and Letizia Polito and Stefania De Mauro and Aikaterini Zisaki and Christina Piperi and Evangelia Stamouli and Antonis Mailis and Sara Batelli and Gianluigi Forloni and Diana de Ronchi and Anastasios Th. Kalofoutis and Ioannis A. Liappas and Alessandro Serretti},
  journal={International journal of geriatric psychiatry},
  volume={25 4},
OBJECTIVE The APOE epsilon-4 allele has consistently emerged as a susceptibility factor for Alzheimer's disease (AD). Pro-inflammatory cytokines are detectable at abnormal levels in AD, and are thought to play a pathophysiological role. Animal studies have shown dose-dependent correlations between the number of APOE epsilon-4 alleles and the levels of pro-inflammatory cytokines. The aims of this study were to investigate the influence of APOE genotypes on TNF-alpha, IL-6, and IL-1beta secreted… CONTINUE READING