APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.

@article{Risacher2015APOEEO,
  title={APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern.},
  author={Shannon L. Risacher and Sungeun Kim and Kwangsik Nho and Tatiana Foroud and Li Shen and Ronald C. Petersen and Clifford R. Jack and Laurel A Beckett and Paul S. Aisen and Robert A. Koeppe and William J. Jagust and Leslie M. Shaw and John Q. Trojanowski and Michael W Weiner and Andrew J. Saykin},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2015},
  volume={11 12},
  pages={1417-1429}
}
INTRODUCTION This study assessed apolipoprotein E (APOE) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC). METHODS Cognitively normal, SMC, and early mild cognitive impairment participants from Alzheimer's Disease Neuroimaging Initiative were divided by APOE ε4 carrier status. Diagnostic and APOE effects were evaluated with emphasis on SMC. Additional analyses in SMC… CONTINUE READING
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