APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.

@article{Colton2002APOEAT,
  title={APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.},
  author={Carol A. Colton and Candice M Brown and Danielle Cook and Leila K Needham and Qing Xu and Meggan Czapiga and Ann M Saunders and Donald E. Schmechel and Karima Rasheed and Michael P Vitek},
  journal={Neurobiology of aging},
  year={2002},
  volume={23 5},
  pages={777-85}
}
The mechanism linking the APOE4 gene with increased susceptibility for Alzheimer's disease (AD) and poorer outcomes following closed head injury and stroke is unknown. One potential link is activation of the innate immune system in the CNS. Our previously published data demonstrated that apolipoprotein E regulates production of nitric oxide, a critical cytoactive factor released by immune active macrophages. To determine if immune regulation is different in the presence of apolipoprotein E4… CONTINUE READING

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