APOE and cerebral amyloid angiopathy in the elderly.

  title={APOE and cerebral amyloid angiopathy in the elderly.},
  author={Seth Love and James A. R. Nicoll and Anthony Hughes and G. K. Wilcock},
  volume={14 11},
Over 30% of normal elderly people have cerebral amyloid angiopathy (CAA). Possession of APOE epsilon4 is associated with increased prevalence and severity of CAA in Alzheimer's disease (AD) and in cerebral haemorrhage. We examined CAA in relation to APOE genotype in brains from 152 people aged 60-102 years, without AD or cerebral haemorrhage. Prevalence of CAA increased with age (p = 0.003). CAA was not associated with APOE genotype. The frequency of epsilon4 showed a significant negative… CONTINUE READING
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