APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults.

@article{Zhang2017APOEAK,
  title={APOE and KIBRA Interactions on Brain Functional Connectivity in Healthy Young Adults.},
  author={Ningnannan Zhang and Huaigui Liu and Wen Qin and Bing Liu and Tianzi Jiang and Chunshui Yu},
  journal={Cerebral cortex},
  year={2017},
  volume={27 10},
  pages={
          4797-4805
        }
}
Genetic variations of APOE and KIBRA have been associated with human memory and Alzheimer's disease. APOE and KIBRA can jointly modulate glutamate receptor to influence long-term potentiation; however, their interactions on brain functional connectivity remain unknown. Here, we investigated additive and epistatic interactions between APOE and KIBRA (rs17070145) on brain functional connectivity density (FCD) in 267 healthy young adults. A voxel-based FCD analysis was performed to identify brain… CONTINUE READING
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