APOE and Alzheimer disease: a major gene with semi-dominant inheritance

  title={APOE and Alzheimer disease: a major gene with semi-dominant inheritance},
  author={Emmanuel G{\'e}nin and Didier Hannequin and David Wallon and Kristel Sleegers and Mikko Hiltunen and Onofre Combarros and M J Bullido and Sebastiaan Engelborghs and P P De Deyn and C Berr and Florence Pasquier and Bruno Dubois and Gloria Tognoni and Nathalie Fievet and Niels Brouwers and Karolien Bettens and Beatrice Arosio and Elicer Coto and Maria Del Zompo and Ignacio Mateo and Jacques Epelbaum and Ana Frank-Garc{\'i}a and Seppo Helisalmi and Elisa Porcellini and Alberto Pilotto and Paola Forti and Roberto Ferri and Elio Scarpini and Gabriele Siciliano and Vincenzo Solfrizzi and Sandro Sorbi and Gianfranco Spalletta and Francisca Valdivieso and Saila Veps{\"a}l{\"a}inen and V. Gonz{\'a}lez {\'A}lvarez and P. I. Bosco and M Mancuso and Francesco Panza and Benedetta Nacmias and Paola Boss{\`u} and Oliver Hanon and Paola Piccardi and Giorgio Annoni and Davide Seripa and D Galimberti and Federico Licastro and Hilkka Soininen and J F Dartigues and M. Ilyas Kamboh and Christine Van Broeckhoven and Jean Charles Lambert and Philippe Amouyel and Dominique Campion},
  journal={Molecular Psychiatry},
Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are currently not accurately known and odds ratios alone are insufficient to assess these risks. We calculated AD LTR in 7351 cases and 10 132 controls from Caucasian ancestry using Rochester (USA) incidence data. At the age of 85 the LTR of AD without reference to APOE genotype was 11% in males and 14% in females. At the same age, this risk ranged from 51% for APOE44 male carriers to 60% for APOE44 female… CONTINUE READING
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Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.

  • J. C. Lambert, S. Heath
  • Nat Genet
  • 2009

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