APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction

@inproceedings{Soto2015APOESB,
  title={APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction},
  author={Ileana Soto and L C Fudd Graham and Hannah Richter and Stephen N. Simeone and Jake E. Radell and Weronika A. Grabowska and William K. Funkhouser and Megan C. Howell and Gareth R. Howell and Hugo J. Bellen},
  booktitle={PLoS biology},
  year={2015}
}
Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolution histological analyses to show that aging leads to a significant deterioration of neurovascular structures including basement membrane reduction, pericyte loss, and astrocyte dysfunction. Neurovascular decline was sufficient to cause vascular… CONTINUE READING
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