APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia.

@article{Josephs2014APOEI,
  title={APOE ε4 influences β-amyloid deposition in primary progressive aphasia and speech apraxia.},
  author={Keith A. Josephs and Joseph R. Duffy and Edythe A. Strand and Mary M. Machulda and Matthew L. Senjem and Val J. Lowe and Clifford R. Jack and Jennifer L. Whitwell},
  journal={Alzheimer's & dementia : the journal of the Alzheimer's Association},
  year={2014},
  volume={10 6},
  pages={630-6}
}
BACKGROUND Apolipoprotein E ε4 (APOE ε4) is a risk factor for β-amyloid deposition in Alzheimer's disease dementia. Its influence on β-amyloid deposition in speech and language disorders, including primary progressive aphasia (PPA), is unclear. METHODS One hundred thirty subjects with PPA or progressive speech apraxia underwent APOE genotyping and Pittsburgh compound B (PiB) PET scanning. The relationship between APOE ε4 and PiB status, as well as severity and regional distribution of PiB… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 4 times over the past 90 days. VIEW TWEETS