# APOE ε4 and the long arm of social inequity: estimated effects of socio-economic status and sex on the timing of dementia onset

@article{Hasselgren2018APOEA,
title={APOE $\epsilon$4 and the long arm of social inequity: estimated effects of socio-economic status and sex on the timing of dementia onset},
author={Caroline Hasselgren and Hans Ekbrand and Madeleine Mellqvist F{\"a}ssberg and Anna Zettergren and Henrik Zetterberg and Kaj Blennow and Ingmar Skoog and Bj{\"o}rn Haller{\"o}d},
journal={Ageing and Society},
year={2018},
volume={39},
pages={1951 - 1975}
}
ABSTRACT It is well established that carriers of the apolipoprotein E (APOE) ε4 allele run a greater risk of developing Alzheimer's disease, the most common form of dementia and a strongly age-related condition known to disproportionally affect women. Low educational attainment also stands out as a prominent risk factor, and it has been suggested that occupational class plays a similar role in disease susceptibility. Not yet fully explored, however, is the question of whether socio-economic… Expand
4 Citations
Socioeconomic status, gender and dementia: The influence of work environment exposures and their interactions with APOE ɛ4
It is proposed that gender- and class-based inequities interact, and hence must be considered simultaneously, also in relation to this particular disease, and the importance of considering interactions between social and genetic risk factors to better understanding multifactorial diseases such as dementia is underscored. Expand
The impact of social networks and APOE ε4 on dementia among older adults: tests of possible interactions
The results underline the importance of strong social networks in postponing dementia onset and indicate that their impact may differ among men and women. Expand
Sex differences in dementia: on the potentially mediating effects of educational attainment and experiences of psychological distress
It is suggested that social (dis) advantage predicts general psychological distress, which thereby constitutes a potential, and rarely acknowledged, pathway between female sex, education, and dementia. Expand
Dissecting the role of Amerindian genetic ancestry and the ApoE ε4 allele on Alzheimer disease in an admixed Peruvian population
The results showed that the risk for AD from ApoE ε4 in Peruvians is higher than the authors have observed in non-Hispanic white populations and supports the findings of an interaction between the genetic risk allele Apo E ε 4 and the ancestral backgrounds located around the genomic region ofApoE gene. Expand

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