APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease

@article{Michaelson2014APOET,
  title={APOE ε4: The most prevalent yet understudied risk factor for Alzheimer's disease},
  author={Daniel Morris. Michaelson},
  journal={Alzheimer's & Dementia},
  year={2014},
  volume={10},
  pages={861-868}
}
Brain pathology of Alzheimer's diseases (AD) and the genetics of autosomal dominant familial AD have been the "lamp posts" under which the AD field has been looking for therapeutic targets. Although this approach still remains valid, none of the compounds tested to date have produced clinically meaningful results. This calls for developing complementary therapeutic approaches and AD targets. The allele ε4 of apolipoprotein E4 (APOE ε4), is the most prevalent genetic risk factor for sporadic AD… CONTINUE READING
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