APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease.

@article{Barabash2009APOEAA,
  title={APOE, ACT and CHRNA7 genes in the conversion from amnestic mild cognitive impairment to Alzheimer's disease.},
  author={Ana Barabash and Alberto Garc{\'i}a Marcos and In{\'e}s Anc{\'i}n and Blanca M. V{\'a}zquez-{\'A}lvarez and Carmen De Ugarte and Pedro Mazeda Gil and Cristina Fernandez and Marta Encinas and Juan Jos{\'e} L{\'o}pez-Ibor and Jos{\'e} Antonio Cabranes},
  journal={Neurobiology of aging},
  year={2009},
  volume={30 8},
  pages={1254-64}
}
We have investigated whether the -86 C/T promoter polymorphism in CHRNA7 gene, the signal peptide polymorphism of the alpha1-antichymotripsin (ACT) gene or the APOE genotype are associated with an increased risk of mild cognitive impairment (MCI) or affect the risk of evolution to Alzheimer's disease (AD). We have followed up 89 patients with initial diagnoses of amnestic MCI for 49 months. Patients were separated into three groups: 27 subjects who remained with MCI, 40 that converted to AD… CONTINUE READING

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