APOBECs orchestrate genomic and epigenomic editing across health and disease.

@article{CervantesGracia2021APOBECsOG,
  title={APOBECs orchestrate genomic and epigenomic editing across health and disease.},
  author={Karla Cervantes-Gracia and Anna Gramalla-Schmitz and Julian Weischedel and Richard Chahwan},
  journal={Trends in genetics : TIG},
  year={2021}
}
6 Citations

The Methylation Game: Epigenetic and Epitranscriptomic Dynamics of 5-Methylcytosine

This work has revealed extensive crosstalk between epigenetic and epitranscriptomic pathways, adding a new layer of complexity to the understanding of cellular programming and responses to environmental cues.

Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells

To precisely follow the possible activation-induced changes in expression levels of APOBEC3 protein in different mouse tissues and cell populations, genome editing was utilized to establish knock-in mice that express APOBec3 protein with an in-frame FLAG tag.

Expression of Human Endogenous Retroviruses in the Human Thymus Along T Cell Development

A tight regulation of HERV expression during human T cell development is found, with possible implications for the process of T cell selection, as well as the interplay with host restriction factors and potential underlying pathways.

Singularity and Commonality in Response to SARS-CoV-2 in Lung and Colon Cell Models

This study provides gene expression level evidence for the cellular responses attributed to pulmonary and gastrointestinal manifestations of COVID-19 and proposes APOBEC3G as a promising intrinsic antiviral factor of the host response to SARS-CoV-2.

Integrative OMICS Data-Driven Procedure Using a Derivatized Meta-Analysis Approach

A new unifying, scalable and straightforward methodology to meta-analyze different omics outputs, but also to integrate the significant outcomes into novel pathways describing biological processes of interest is described.

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