APOBEC4 Enhances the Replication of HIV-1

@article{Marino2016APOBEC4ET,
  title={APOBEC4 Enhances the Replication of HIV-1},
  author={Daniela Marino and Mario Perkovi{\'c} and Anika Hain and A. A. Jaguva Vasudevan and H. Hofmann and K. Hanschmann and M. M{\"u}hlebach and G. Schumann and R. K{\"o}nig and K. Cichutek and D. H{\"a}ussinger and C. M{\"u}nk},
  journal={PLoS ONE},
  year={2016},
  volume={11}
}
APOBEC4 (A4) is a member of the AID/APOBEC family of cytidine deaminases. In this study we found a high mRNA expression of A4 in human testis. In contrast, there were only low levels of A4 mRNA detectable in 293T, HeLa, Jurkat or A3.01 cells. Ectopic expression of A4 in HeLa cells resulted in mostly cytoplasmic localization of the protein. To test whether A4 has antiviral activity similar to that of proteins of the APOBEC3 (A3) subfamily, A4 was co-expressed in 293T cells with wild type HIV-1… Expand
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APOBEC: From mutator to editor.
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