APOBEC3DE Inhibits LINE-1 Retrotransposition by Interacting with ORF1p and Influencing LINE Reverse Transcriptase Activity

@inproceedings{Liang2016APOBEC3DEIL,
  title={APOBEC3DE Inhibits LINE-1 Retrotransposition by Interacting with ORF1p and Influencing LINE Reverse Transcriptase Activity},
  author={Weizi Liang and Jiwei Xu and Wensu Yuan and Xuan Bo Song and Jianyong Zhang and Wei Wei and Xiao-fang Yu and Ying Yang},
  booktitle={PloS one},
  year={2016}
}
Human long interspersed elements 1 (LINE-1 or L1) is the only autonomous non-LTR retroelement in humans and has been associated with genome instability, inherited genetic diseases, and the development of cancer. Certain human APOBEC3 family proteins are known to have LINE-1 restriction activity. The mechanisms by which APOBEC3 affects LINE-1 retrotransposition are not all well characterized; here, we confirm that both A3B and A3DE have a strong ability to inhibit LINE-1 retrotransposition. A3DE… CONTINUE READING

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