APOBEC3 cytidine deaminases in double-strand DNA break repair and cancer promotion.

Abstract

High frequency of cytidine to thymidine conversions was identified in the genome of several types of cancer cells. In breast cancer cells, these mutations are clustered in long DNA regions associated with single-strand DNA (ssDNA), double-strand DNA breaks (DSB), and genomic rearrangements. The observed mutational pattern resembles the deamination signature… (More)
DOI: 10.1158/0008-5472.CAN-13-0728

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