APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia

@article{Wang2008APOA5GV,
  title={APOA5 genetic variants are markers for classic hyperlipoproteinemia phenotypes and hypertriglyceridemia},
  author={Jian Wang and Matthew R. Ban and Brooke A. Kennedy and Sonia Taj Anand and Salim Yusuf and Murray W. Huff and Rebecca L. Pollex and Robert A Hegele},
  journal={Nature Clinical Practice Cardiovascular Medicine},
  year={2008},
  volume={5},
  pages={730-737}
}
Background Several known candidate gene variants are useful markers for diagnosing hyperlipoproteinemia. In an attempt to identify other useful variants, we evaluated the association of two common APOA5 single-nucleotide polymorphisms across the range of classic hyperlipoproteinemia phenotypes.Methods We assessed plasma lipoprotein profiles and APOA5 S19W and −1131T>C genotypes in 678 adults from a single tertiary referral lipid clinic and in 373 normolipidemic controls matched for age and sex… CONTINUE READING

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