APJ ACTS AS A DUAL RECEPTOR IN CARDIAC HYPERTROPHY

@article{Scimia2012APJAA,
  title={APJ ACTS AS A DUAL RECEPTOR IN CARDIAC HYPERTROPHY},
  author={M. C. Scimia and C. Hurtado and S. Ray and Scott Metzler and K. Wei and J. Wang and Chris E. Woods and N. Purcell and D. Catalucci and T. Akasaka and O. F. Bueno and G. Vlasuk and P. Kaliman and R. Bodmer and L. Smith and E. Ashley and M. Mercola and Joan Heller Brown and P. Ruiz-Lozano},
  journal={Nature},
  year={2012},
  volume={488},
  pages={394 - 398}
}
  • M. C. Scimia, C. Hurtado, +16 authors P. Ruiz-Lozano
  • Published 2012
  • Biology, Medicine
  • Nature
  • Cardiac hypertrophy is initiated as an adaptive response to sustained overload but progresses pathologically as heart failure ensues. Here we report that genetic loss of APJ, a G-protein-coupled receptor, confers resistance to chronic pressure overload by markedly reducing myocardial hypertrophy and heart failure. In contrast, mice lacking apelin (the endogenous APJ ligand) remain sensitive, suggesting an apelin-independent function of APJ. Freshly isolated APJ-null cardiomyocytes exhibit an… CONTINUE READING
    158 Citations

    Paper Mentions

    Interventional Clinical Trial
    The investigators hypothesised that novel MRI metrics derived from myocardium post-gadolinium T1 mapping analysis will improve the current knowledge about the role interstitial fibrosis… Expand
    ConditionsHeart Failure
    InterventionOther
    Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
    • 21
    Lactation Is a Risk Factor of Postpartum Heart Failure in Mice with Cardiomyocyte-specific Apelin Receptor (APJ) Overexpression*
    • 7
    • PDF
    ELABELA-APJ axis protects from pressure overload heart failure and angiotensin II-induced cardiac damage
    • 52
    • PDF
    A novel APJ signaling cascade that regulates cardiovascular development.
    • 6
    • PDF
    Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling
    • 16
    • PDF
    Apelin is a positive regulator of ACE2 in failing hearts.
    • 106
    • PDF
    Elabela-APJ axis: a novel therapy target for cardiovascular diseases
    • 3
    • PDF

    References

    SHOWING 1-10 OF 36 REFERENCES
    Endogenous regulation of cardiovascular function by apelin-APJ.
    • 160
    • PDF
    Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis.
    • 269
    • PDF
    G protein-coupled receptor signalling in in vivo cardiac overload.
    • 10
    Apelin, the Novel Endogenous Ligand of the Orphan Receptor APJ, Regulates Cardiac Contractility
    • 355
    • PDF
    The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy.
    • 293